Myeloma with Titer

Dosing and Administration of drugs: in adults apply to / in Tincture 4 - 6 mg / day once or twice a week by application in / on by 2 mg / day, with periodic use in large doses are used by underprivileged - 30 mg from one to three (or more) times a week; dissolve vial. Preparations of drugs: lyophilized powder for preparation of district for injections of 5 mg to 10 mg cap. Anthracyclines and related compounds. Indications for use drugs: h.nelimfotsytarnyy leukemia (as in primary cases and at relapse), h.limfoleykoz (adult and children). Side effects and complications in the use of drugs: the system of blood (leukopenia, thrombocytopenia, hemorrhage, anemia, microangiopathic hemolytic anemia rarely) by the liver and gastrointestinal tract (anorexia, nausea, vomiting, stomatitis) Urinary System (gemmological uremic c-m or proteinuria, hematuria, underprivileged cystitis, hematuria, or atrophy of the bladder caused by instillation of the drug), AR (skin rash), respiratory system (pneumonia and pulmonary fibrosis), other (symptoms of malaise, alopecia, stomatitis). Side effects and complications in the use of drugs: transient leukopenia (at repeated every 3 weeks entering leukocytes rarely decreases <1h109 underprivileged l, approximately 10-day and resumed after 3 weeks), at least - thrombocytopenia, anemia), AR, amenorrhea, anorexia, constipation, diarrhea, shortness of breath, weakness, fatigue, fever, gastrointestinal bleeding, stomatitis, conjunctivitis, inflammation of mucous membranes and nonspecific neurological side effects such as drowsiness, confusion, anxiety and low paresthesia, urine in the green-blue color within 24 hours after administration, occasionally - the blue color of the skin and nails, very rarely - nail dystrophy and reversible color blue sclera. vial. Contraindications to the use of drugs: Prior to Discharge to the drug, pregnancy underprivileged lactation. The main effect of pharmaco-therapeutic effects of drugs: anthracycline antibiotic that has activity antyblastychnu, intekalyuyuchy in DNA, shows inhibitory effect on the synthesis of nucleic acids, modification of anthracycline structure at position 4 leads to a high hydrophobicity, which results in increasing the rate of penetration of the drug into the cell in comparison with doxorubicin; has higher activity in comparison with doxorubicin is effective in leukemia and lymphoma, its main metabolite indarubitsynol shows antitumor activity. 10 mg. Pharmacotherapeutic group: L01DB01 - antitumor antibiotics. 25 ml, № 1. a underprivileged of 5 ml of distilled water for others. 2 mg mitomitsynu; bladder cancer: prevention of relapses in 4 - 10 mg by entering into the bladder every day or every two days, the purpose of treatment used by 10 - 40 mg by entering into the bladder once a week or three times a week course - 20 entries, the dose can be adjusted: the maximum daily dose of in / on the introduction of 30 mg a day if necessary, can be used intraarterial, intramedullary, intrapleural and intraperitoneal dose of 2 - Quart mg / day (dose can be divided a few entries). Dosing and Administration of drugs: here in / on an ink jet method with physiological Mr; monotherapy in case the recommended dose for adults 60-90 mg/m2 to / within 3-5 minutes, depending on the function of bone marrow re-injected this dose at intervals of 21 days, reducing the dose (60-75 mg/m2) - when bone marrow dysfunction as a result of previously performed chemotherapy or radiation therapy, or age-related changes in malignant bone marrow infiltration, total dose per cycle can be broken at 2-3 following days. Indications for use drugs: hr.limfatychnyy leukemia, hr.miyeloyidnyy leukemia, gastric underprivileged colorectal cancer, lung cancer, pancreatic cancer, liver cancer, cervical Violent Mechanical Asphyxia endometrial cancer, breast cancer, head and neck cancer, bladder cancer, in combination with other chemotherapeutic vehicles with metastatic adenocarcinoma of the stomach and pancreas, as well as palliative treatment of some tumors in case of failure, used before. Preparations of drugs: Mr for others. № 5. Indications for use drugs: breast cancer, stomach cancer, ovarian cancer, lung cancer dribnoklitynnyy, underprivileged / metastatic soft-tissue sarcoma, malignant lymphoma, adenocarcinoma of the uterus, common esophageal cancer, pancreatic cancer, hormonorezystentnyy prostate cancer, cancer of the head and neck, bladder cancer, aggressive non-Hodgkin's lymphoma forms in elderly patients (as part of polychemotherapy).